The Oral History of Hagar Omran, "Zawam" Readings for Diversity and Social Justice

Papers

Egyptian Journal of Medical Human Genetics , 2021

Long non-coding RNAs (LncRNAs) have recently been considered promising biomarkers for oncogenesis... more Long non-coding RNAs (LncRNAs) have recently been considered promising biomarkers for oncogenesis due to their epigenetic regulatory effects. HOTAIR is one of the oncogenic LncRNAs that was previously studied in different not-hematological malignancies. The electric current study set out to notice the expression level of HOTAIR LncRNA in AML patients concerning their clinical characteristics, laboratory information, FLT3-ITD, and NPM1 mutations, equally well as handling outcome. This written report included quantitative detection of HOTAIR gene expression in 47 cases of AML using quantitative reverse transcription polymerase chain reaction, likewise as NPM1 and FLT3-ITD genotyping. The HOTAIR expression was significantly college in AML patients 6.87 (0.001) than in normal controls 1.66 (0.004–6.82) (p 0.007). The HOTAIR expression level was affected past chemotherapy, and it was correlated to hemoglobin level (p 0.001), historic period, total leukocytic count (p 0.022), and NPM1 mutation (p 0.017). HOTAIR gene expression level...

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Journal of Clinical and Analytical Medicine , 2017

1 Hamdy Yard. Zawam1, Mohsen Grand. Mokhtar1, Rasha Salama1, Samy A. Alsirafy2, Mai K. Bishr1,3 1Kasr Al... more one Hamdy M. Zawam1, Mohsen Thousand. Mokhtar1, Rasha Salama1, Samy A. Alsirafy2, Mai G. Bishr1,3 1Kasr Al-Ainy Heart of Clinical Oncology & Nuclear Medicine (NEMROCK), Cairo University, Cairo, Arab republic of egypt, 2Palliative Medicine Unit, Kasr Al-Ainy Center of Clinical Oncology & Nuclear Medicine (NEMROCK), Cairo Academy, Cairo, Egypt, 3Department of Radiotherapy, Children'southward Cancer Infirmary Egypt (CCHE), Cairo, Arab republic of egypt Acute promyelocytic leukemia Factors affecting treatment result of acute promyelocytic leukemia in Egyptian patients

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Periodical of the Egyptian National Cancer Institute , 2013

Transcription factors play a crucial role in myeloid differentiation and lineage determination. T... more Transcription factors play a crucial role in myeloid differentiation and lineage decision. Tumor suppressor protein C/EBPa is a cardinal regulator of granulocytic differentiation whose functional inactivation has become a pathophysiological signature of myeloid leukemia. Given the function that CCAAT/enhancer bounden protein α (C/EBP α) plays in myelopoiesis, we predictable that their expression might exist disrupted in myeloid neoplasms. To estimate the expression of C/EBPα mRNA in patients with astute myeloid leukemia and correlate its expression with the pathogenesis of the disease. Forty AML patients and 20 age and sexual practice matched healthy controls were included in the study. Claret samples of patients and controls were analyzed for CEBPα mRNA expression by quantitative RT-existent fourth dimension PCR using TaqMan engineering & ΔΔCt method for calculation of gene expression. Twenty-nine (72.5%) patients out of the 40 showed low expression levels of CEBPα mRNA beneath the cutoff value with median of 0.19 (range:0-0.87). While xi (27.5%) patients out of the 40 showed college expression levels of CEBPα above the cutoff value with median of one.52 (range:ane.07-ii). Seven patients out of the 11 showed higher expression levels of CEBPα mRNA belong to the M3 subtype of AML harboring the t(fifteen;17) PML-RARa translocation. Nosotros conclude that the majority of the AML patients analyzed, express low levels of C/EBPa mRNA. However, a subset of patients represented past the M3 subtype, express higher levels of C/EBPa.

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Journal of the Egyptian National Cancer Constitute , 2014

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Periodical of Cancer Inquiry and Clinical Oncology , 2014

Multidrug resistance (MDR1) represents a major obstacle in the chemotherapeutic treatment of acut... more Multidrug resistance (MDR1) represents a major obstacle in the chemotherapeutic treatment of astute leukemia (AL). Adenosine triphosphate ATP-binding cassette (ABCB5) and MDR1 genes are integral membrane proteins belonging to ATP-binding cassette transporters superfamily. The present piece of work aimed to investigate the bear on of ABCB5 and MDR1 genes expression on the response to chemotherapy in a accomplice of Egyptian AL patients. The written report included xc patients: 53 AML cases and 37 ALL cases in addition to xx salubrious volunteers as controls. Quantitative assessment of MDR1 and ABCB5 genes expression was performed by quantitative real-time polymerase chain reaction. Additional prognostic molecular markers were adamant every bit internal tandem duplications of the FLT3 cistron (FLT3-ITD) and nucleophosmin gene mutation (NPM1) for AML cases, and mbcr-abl fusion transcript for B-ALL cases. In AML patients, ABCB5 and MDR1 expression levels did not differ significantly between de novo and relapsed cases and did not correlate with the overall survival or affliction-gratis survival. AML patients were stratified according to the studied genetic markers, and complete remission rate was plant to exist more prominent in patients having low expression of MDR1 and ABCB5 genes together with mutated NPM1 gene. In ALL patients, ABCB5 gene expression level was significantly higher in relapsed cases and MDR1 factor expression was significantly college in patients with resistant disease. In decision, the results obtained by the current study provide additional prove of the part played by these genes as predictive factors for resistance of leukemic cells to chemotherapy and hence treatment outcome.

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Infection, Genetics and Evolution , 2012

ABSTRACT Hepatitis C virus (HCV) has been postulated to exist an etiological agent for lymphoid mali... more Abstruse Hepatitis C virus (HCV) has been postulated to be an etiological agent for lymphoid malignancies. Polymorphisms in oxidative stress genes as; superoxide dismutase (SOD2), glutathione peroxidase (GPX1), catalase (CAT), myeloperoxidase (MPO) and nitric oxide synthase (NOS2) may influence non-Hodgkin's lymphoma (NHL) take a chance. HCV screening and polymorphisms in these five genes coding for antioxidant enzymes were studied in 100 Egyptian patients with B cell-NHL and 100 controls to clarify the association between HCV infection, oxidative stress genes polymorphisms and B cell-NHL run a risk. A significantly higher prevalence of HCV infection was detected among NHL patients relative to controls and this carried a 14-fold increased NHL run a risk (odds ratio (OR)=xiv.three, 95% confidence interval (CI)=5.iv-38.3, p<0.0001). GPX1 and MPO genetic polymorphisms conveyed increment in B-NHL risk (OR=3.3, 95% CI=1.4-7.4, p=0.004 and OR=4.4, 95% CI=1.3-14.2, p=0.009 respectively). Farther analyses stratified past HCV infection revealed that concomitant HCV infection and GPX1 gene polymorphism had a synergetic effect on NHL risk with an OR of 15 (95%CI=2.2-69.half dozen, p<0.0001). In improver, combined HCV infection and MPO gene polymorphisms had a pronounced NHL risk (OR=nine.2, 95%CI=two.5-33.9, p<0.0001). SOD2, True cat and NOS2 genetic polymorphisms were not constitute to confer increased NHL take a chance. This study revealed that HCV infection is a gamble cistron for NHL in Arab republic of egypt. Polymorphisms in GPX1 and MPO genes may influence NHL risk in HCV infected Egyptian patients. Larger scale studies are warranted to institute this genetic susceptibility for NHL.

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Journal of the Egyptian Womenʼs Dermatologic Guild , 2015

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Egyptian Journal of Medical Man Genetics , 2021

Long non-coding RNAs (LncRNAs) have recently been considered promising biomarkers for oncogenesis... more Long non-coding RNAs (LncRNAs) have recently been considered promising biomarkers for oncogenesis due to their epigenetic regulatory effects. HOTAIR is one of the oncogenic LncRNAs that was previously studied in different not-hematological malignancies. The current study set out to notice the expression level of HOTAIR LncRNA in AML patients concerning their clinical characteristics, laboratory data, FLT3-ITD, and NPM1 mutations, too as treatment outcome. This report included quantitative detection of HOTAIR gene expression in 47 cases of AML using quantitative reverse transcription polymerase chain reaction, as well equally NPM1 and FLT3-ITD genotyping. The HOTAIR expression was significantly higher in AML patients 6.87 (0.001) than in normal controls 1.66 (0.004–half-dozen.82) (p 0.007). The HOTAIR expression level was afflicted by chemotherapy, and it was correlated to hemoglobin level (p 0.001), age, total leukocytic count (p 0.022), and NPM1 mutation (p 0.017). HOTAIR gene expression level...

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Journal of Clinical and Analytical Medicine , 2017

1 Hamdy 1000. Zawam1, Mohsen M. Mokhtar1, Rasha Salama1, Samy A. Alsirafy2, Mai K. Bishr1,3 1Kasr Al... more 1 Hamdy G. Zawam1, Mohsen M. Mokhtar1, Rasha Salama1, Samy A. Alsirafy2, Mai K. Bishr1,3 1Kasr Al-Ainy Heart of Clinical Oncology & Nuclear Medicine (NEMROCK), Cairo Academy, Cairo, Egypt, 2Palliative Medicine Unit, Kasr Al-Ainy Center of Clinical Oncology & Nuclear Medicine (NEMROCK), Cairo University, Cairo, Egypt, 3Department of Radiotherapy, Children'southward Cancer Hospital Egypt (CCHE), Cairo, Egypt Astute promyelocytic leukemia Factors affecting treatment upshot of acute promyelocytic leukemia in Egyptian patients

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Periodical of the Egyptian National Cancer Institute , 2013

Transcription factors play a crucial part in myeloid differentiation and lineage determination. T... more Transcription factors play a crucial role in myeloid differentiation and lineage determination. Tumor suppressor poly peptide C/EBPa is a key regulator of granulocytic differentiation whose functional inactivation has become a pathophysiological signature of myeloid leukemia. Given the function that CCAAT/enhancer binding protein α (C/EBP α) plays in myelopoiesis, we anticipated that their expression might exist disrupted in myeloid neoplasms. To estimate the expression of C/EBPα mRNA in patients with astute myeloid leukemia and correlate its expression with the pathogenesis of the disease. Twoscore AML patients and twenty age and sex matched good for you controls were included in the study. Blood samples of patients and controls were analyzed for CEBPα mRNA expression by quantitative RT-real time PCR using TaqMan technology & ΔΔCt method for calculation of gene expression. Xx-ix (72.five%) patients out of the 40 showed low expression levels of CEBPα mRNA below the cutoff value with median of 0.19 (range:0-0.87). While 11 (27.5%) patients out of the 40 showed higher expression levels of CEBPα higher up the cutoff value with median of 1.52 (range:1.07-2). Seven patients out of the 11 showed college expression levels of CEBPα mRNA vest to the M3 subtype of AML harboring the t(xv;17) PML-RARa translocation. We conclude that the bulk of the AML patients analyzed, limited low levels of C/EBPa mRNA. Nevertheless, a subset of patients represented by the M3 subtype, express college levels of C/EBPa.

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Journal of the Egyptian National Cancer Constitute , 2014

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Journal of Cancer Research and Clinical Oncology , 2014

Multidrug resistance (MDR1) represents a major obstacle in the chemotherapeutic treatment of acut... more Multidrug resistance (MDR1) represents a major obstruction in the chemotherapeutic treatment of acute leukemia (AL). Adenosine triphosphate ATP-binding cassette (ABCB5) and MDR1 genes are integral membrane proteins belonging to ATP-binding cassette transporters superfamily. The present piece of work aimed to investigate the impact of ABCB5 and MDR1 genes expression on the response to chemotherapy in a cohort of Egyptian AL patients. The report included xc patients: 53 AML cases and 37 ALL cases in improver to 20 good for you volunteers as controls. Quantitative assessment of MDR1 and ABCB5 genes expression was performed past quantitative existent-time polymerase chain reaction. Boosted prognostic molecular markers were determined as internal tandem duplications of the FLT3 gene (FLT3-ITD) and nucleophosmin cistron mutation (NPM1) for AML cases, and mbcr-abl fusion transcript for B-ALL cases. In AML patients, ABCB5 and MDR1 expression levels did not differ significantly betwixt de novo and relapsed cases and did not correlate with the overall survival or disease-free survival. AML patients were stratified according to the studied genetic markers, and complete remission rate was found to be more prominent in patients having low expression of MDR1 and ABCB5 genes together with mutated NPM1 gene. In ALL patients, ABCB5 gene expression level was significantly higher in relapsed cases and MDR1 gene expression was significantly higher in patients with resistant disease. In conclusion, the results obtained by the current report provide additional evidence of the function played by these genes every bit predictive factors for resistance of leukemic cells to chemotherapy and hence treatment upshot.

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Infection, Genetics and Development , 2012

ABSTRACT Hepatitis C virus (HCV) has been postulated to be an etiological amanuensis for lymphoid mali... more Abstruse Hepatitis C virus (HCV) has been postulated to be an etiological agent for lymphoid malignancies. Polymorphisms in oxidative stress genes equally; superoxide dismutase (SOD2), glutathione peroxidase (GPX1), catalase (CAT), myeloperoxidase (MPO) and nitric oxide synthase (NOS2) may influence not-Hodgkin'due south lymphoma (NHL) risk. HCV screening and polymorphisms in these five genes coding for antioxidant enzymes were studied in 100 Egyptian patients with B prison cell-NHL and 100 controls to analyze the clan between HCV infection, oxidative stress genes polymorphisms and B cell-NHL hazard. A significantly higher prevalence of HCV infection was detected among NHL patients relative to controls and this carried a 14-fold increased NHL risk (odds ratio (OR)=14.3, 95% confidence interval (CI)=five.4-38.3, p<0.0001). GPX1 and MPO genetic polymorphisms conveyed increment in B-NHL run a risk (OR=3.3, 95% CI=1.4-7.iv, p=0.004 and OR=4.4, 95% CI=1.3-14.2, p=0.009 respectively). Farther analyses stratified by HCV infection revealed that concomitant HCV infection and GPX1 cistron polymorphism had a synergetic effect on NHL risk with an OR of 15 (95%CI=2.2-69.6, p<0.0001). In add-on, combined HCV infection and MPO gene polymorphisms had a pronounced NHL risk (OR=9.2, 95%CI=2.five-33.9, p<0.0001). SOD2, True cat and NOS2 genetic polymorphisms were not found to confer increased NHL risk. This study revealed that HCV infection is a risk factor for NHL in Arab republic of egypt. Polymorphisms in GPX1 and MPO genes may influence NHL risk in HCV infected Egyptian patients. Larger scale studies are warranted to establish this genetic susceptibility for NHL.

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Periodical of the Egyptian Womenʼs Dermatologic Society , 2015

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Source: https://independent.academia.edu/HZawam